Built for the work between radiochemistry

and biological discovery

This NCI-developed illumiQ platform is intended to help researchers connect prepared activity, administered activity, biodistribution, absorbed dose, and biological response with fewer measurement handoffs and high accuracy and repeatability.

High-impact applications

Where precise micro-activity measurement changes the experiment.

01 / Targeted alpha therapy

Parent–daughter radionuclide studies

Measure low administered activities and investigate daughter redistribution that may alter tumor dose or organ toxicity.

02 / Radiotheranostics

Diagnostic–therapy pair development

Compare surrogate imaging isotopes with therapeutic isotopes across chemistry, pharmacokinetics, and biodistribution.

03 / Biodistribution

Small-animal dose and residuals

Measure the filled syringe, administered dose, residual syringe activity, standards, and harvested samples in a traceable workflow.

04 / Radiochemistry

Tracer development and quality control

Support dilution series, labeling-yield studies, stability checks, and decay-corrected preparation of preclinical doses.

05 / Molecular imaging

PET and SPECT tracer research

Quantify low-activity preparations for scanner calibration, phantom studies, longitudinal imaging, and protocol optimization.

06 / Cell therapy

Radiolabeled immune-cell studies

Measure low activities used to label and track immune cells while minimizing perturbation to cell function.

07 / Pharmacology

ADME and pharmacokinetic studies

Improve activity accounting in absorption, distribution, metabolism, and excretion studies using radiolabeled compounds.

08 / Dosimetry

Dose–response and radiobiology

Link delivered activity to tumor control, normal-tissue effects, and combination-therapy response.

09 / Metrology

Half-life and standardization studies

Follow decay across many half-lives and compare activity determinations with traceable standards and reference systems.

A typical preclinical workflow

From radiosynthesis to biological result.

  1. 1

    Prepare and assay

    Measure the stock, working dilution, and filled administration syringe.

  2. 2

    Administer and re-measure

    Measure post-injection residual activity to calculate the true delivered dose.

  3. 3

    Collect and quantify

    Measure standards, ex vivo tissue samples, or companion isotope preparations.

  4. 4

    Connect activity to outcome

    Use consistent activity data in biodistribution, dosimetry, efficacy, and toxicity analysis.

Preclinical sample measurement in a central well
NCI Developed Prototype: The large central well supports direct measurement of common preclinical sample containers.

Have a difficult radionuclide? Problems with reproducibility? Working on a new technique like quantum PET?

Bring us the measurement problem.

We are prioritizing radionuclides, activity ranges, container geometries, and protocols with direct input from preclinical research teams.

Propose a validation study